4. All Four Stars Passed on the Show
Initially, all four lead characters actually passed on their roles. Debra Messing was just coming off two back-to-back series and felt she was too tired to give another show a shot. Megan Mullally was unsure how to make her character, Karen Walker, unique. Eric McCormack was a little hesitant to play a gay character, according to Mullally, and as for Sean Hayes, “I can’t remember what Sean’s thing was,” Mullally says.
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