10. Regeneration
When William Hartnell began to suffer from arteriosclerosis, the writers were forced to write him out of the show. This real world necessity is what lead to one of the Doctor’s most famous traits: his ability to regenerate. Then showrunner Innes Lloyd decided that when Hartnell left the show, it would be more interesting to swap the main character entirely, giving him a brand new look and personality.
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